SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NEW 1,8-DIAZA-2,9,10-ANTHRACENETRIONE DERIVATIVES

被引：36

作者：

GESTO, C

DELACUESTA, E

AVENDANO, C

EMLING, F

机构：

[1] UNIV COMPLUTENSE MADRID,FAC FARM,DEPT QUIM ORGAN & FARMACEUT,E-28040 MADRID,SPAIN

[2] KNOLL AG,W-6700 LUDWIGSHAFEN,GERMANY

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1992年 / 81卷 / 08期

关键词：

D O I：

10.1002/jps.2600810819

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Diels-Alder heterocycloaddition reactions of 2,5,8-quinolinetriones and 1-azadienes afford 1,8-diaza-2,9,10-anthracenetriones, which are simple analogues of the antitumoral antibiotic diazaquinomicin A. Cytotoxicity in this series and antitumor activity of the lead compound, 6-methyl-1,8-diaza-2,9,10-anthracenetrione, are reported.

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页码：815 / 816

页数：2

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