BRADYKININ INDUCES SUPEROXIDE ANION RELEASE FROM HUMAN ENDOTHELIAL-CELLS

被引:143
作者
HOLLAND, JA
PRITCHARD, KA
PAPPOLLA, MA
WOLIN, MS
ROGERS, NJ
STEMERMAN, MB
机构
[1] NEW YORK MED COLL,DEPT PATHOL,VALHALLA,NY 10595
[2] NEW YORK MED COLL,DEPT PHYSIOL,VALHALLA,NY 10595
[3] VET ADM MED CTR,DEPT MED,MONTROSE,NY 10548
[4] VET ADM MED CTR,DEPT PATHOL,MONTROSE,NY 10548
关键词
D O I
10.1002/jcp.1041430104
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The time‐dependent release of superoxide anion (O 2−) from bradykinin (Bk)‐stimulated human umbilical vein endothelial cells (EC) was measured as the superoxide dismutase‐inhibitable reduction of ferricytochrome C employing a novel application of microspectrophotometry. In the absence of Bk, O 2− release by EC was not detectable. EC exposure to Bk (10−6 to 10−5 M) resulted in a rapid release of O 2−. The release of O 2− occurred within 5 minutes of exposure. O 2− release was partially inhibited by indomethacin (63 ± 6%), thus suggesting that arachidonic acid metabolism, through cyclooxygenase, contributes to EC O 2− production. EC O 2− release may be an important component in the pathophysiologic actions of Bk on vascular function. Copyright © 1990 Wiley‐Liss, Inc.
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页码:21 / 25
页数:5
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