RADIOFREQUENCY ENCODED COMBINATORIAL CHEMISTRY

The combinatorial synthesis of peptides on a support can be traced exactly by the incorporation of semi‐conductor memory chips in Microreactors containing polymer beads (see picture on the right). Before each coupling step the chip is encoded with a radiofrequency signal (for example A); the sequence of signals encoding the complete amino acid sequence (for example A‐B‐A) can be read before or after the oligopeptide is cleaved from the support. This approach was used to construct a 24‐member peptide library from 96 Microreactors and could be applicable to the synthesis of small organic molecule libraries as well. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany