SODIUM-PUMP ISOZYMES ARE DIFFERENTIALLY EXPRESSED IN ELECTRICALLY DISSIMILAR REGIONS OF COLONIC CIRCULAR SMOOTH-MUSCLE

被引：19

作者：

BURKE, EP ^{[1
]}

SANDERS, KM ^{[1
]}

HOROWITZ, B ^{[1
]}

机构：

[1] UNIV NEVADA,SCH MED,DEPT PHYSIOL,RENO,NV 89557

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 06期

关键词：

COLON; NA; K-ATPASE; GENE EXPRESSION;

D O I：

10.1073/pnas.88.6.2370

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Molecular analyses of Na,K-ATPase abundance and alpha-subunit isoform distribution were performed to determine whether pump expression varies at different points through the thickness of the circular layer of colonic smooth muscle. The mRNA and polypeptides of Na,K-ATPase alpha-1 and beta-subunits were twice as abundant in the submucosal region of the circular layer, which has previously been shown to generate large pump potentials. Sodium pump activity directly correlated with the relative abundance of the alpha-1 polypeptide. These data show that sodium pump expression varies in electrically dissimilar regions of the circular layer.

引用

页码：2370 / 2374

页数：5

共 35 条

[1]

BAUER AJ, 1986, GASTROENTEROLOGY, V91, P1045

[2] SLOW-WAVE HETEROGENEITY WITHIN THE CIRCULAR MUSCLE OF THE CANINE GASTRIC ANTRUM [J].