SYNTHESIS AND STRUCTURE ACTIVITY RELATIONSHIP OF SUBSTITUTED TETRAHYDRO AND HEXAHYDRO-1,2-BENZISOTHIAZOL-3-ONE 1,1-DIOXIDES AND THIADIAZINONES - POTENTIAL ANXIOLYTIC AGENTS

被引:47
作者
ABOUGHARBIA, M [1 ]
MOYER, JA [1 ]
PATEL, U [1 ]
WEBB, M [1 ]
SCHIEHSER, G [1 ]
ANDREE, T [1 ]
HASKINS, JT [1 ]
机构
[1] WYETH AYERST RES,DIV EXPTL THERAPEUT,PRINCETON,NJ 08543
关键词
D O I
10.1021/jm00125a016
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1024 / 1033
页数:10
相关论文
共 25 条
[1]   POLYCYCLIC ARYLPIPERAZINYL AND HETEROARYLPIPERAZINYL IMIDES AS 5-HT1A RECEPTOR LIGANDS AND POTENTIAL ANXIOLYTIC AGENTS - SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP STUDIES [J].
ABOUGHARBIA, M ;
PATEL, UR ;
WEBB, MB ;
MOYER, JA ;
ANDREE, TH ;
MUTH, EA .
JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (07) :1382-1392
[2]   PSYCHOTROPIC AGENTS - SYNTHESIS AND ANTIPSYCHOTIC ACTIVITY OF SUBSTITUTED BETA-CARBOLINES [J].
ABOUGHARBIA, M ;
PATEL, UR ;
MOYER, JA ;
MUTH, EA .
JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (06) :1100-1105
[3]   CLIMBING BEHAVIOR INDUCED BY APOMORPHINE IN MICE - POTENTIAL MODEL FOR DETECTION OF NEUROLEPTIC ACTIVITY [J].
COSTALL, B ;
NAYLOR, RJ ;
NOHRIA, V .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 50 (01) :39-50
[4]   REACTION OF SULFAMIDE WITH DIKETENE - SYNTHESIS OF AN S-DIOXO ANALOG OF 6-METHYLURACIL [J].
DIE, R ;
DIEZ, J ;
STUD, M ;
MADRONER.R ;
GARCIAMU.G .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1972, 9 (04) :973-&
[5]   A NOTE ON A SIMPLE APPARATUS FOR DETECTING NEUROLOGICAL DEFICIT IN RATS AND MICE [J].
DUNHAM, NW ;
MIYA, TS .
JOURNAL OF THE AMERICAN PHARMACEUTICAL ASSOCIATION, 1957, 46 (03) :208-209
[6]  
Fielding S., 1978, HDB PSYCHOPHARMACOLO, VVolume 10, P91
[7]  
HASKINS JT, 1987, NEUROSCIENCE S, V22
[8]  
HERMAN RL, 1979, PSYCHOPHARMACOL COMM, V3, P165
[9]  
HIBERT M, 1986, INT S MED CHEM WEST
[10]  
HIROSE A, 1986, JAP J PHARM, V40, P114