Management and Outcome in 32 Neonates with Thrombotic Events

被引：36

作者：

van Elteren, H. A. ^{[1
]}

Veldt, H. S. ^{[1
]}

Pas, A. B. te ^{[1
]}

Roest, A. A. W. ^{[2
]}

Smiers, F. J. ^{[3
]}

Kollen, W. J. ^{[3
]}

Sramek, A. ^{[4
]}

Walther, F. J. ^{[1
]}

Lopriore, E. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Pediat, Div Neonatol, POB 9600, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Pediat, Div Pediat Cardiol, NL-2300 RC Leiden, Netherlands

[3] Leiden Univ, Med Ctr, Dept Pediat, Div Immunol & Hemato Oncol, NL-2300 RC Leiden, Netherlands

[4] Leiden Univ, Med Ctr, Dept Radiol, NL-2300 RC Leiden, Netherlands

来源：

INTERNATIONAL JOURNAL OF PEDIATRICS | 2011年 / 2011卷

关键词：

D O I：

10.1155/2011/217564

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective. To determine the incidence, management, complications, and outcome in neonates with thrombotic events. Study Design. We performed a retrospective study of all neonates with thrombotic events admitted to our neonatal intensive care unit from January 2004 to July 2010. Results. Thrombotic events were identified in 32 of 4734 neonates (0.7%). Seven neonates were managed expectantly and 25 neonates received anticoagulant treatment. Complete resolution of the clot within 3 months of age was found in 68% (17/25) of the treated and in 86% (6/7) of the nontreated neonates. Major complications due to anticoagulant therapy occurred in 3/25 cases (12%) and included severe hemorrhage (n = 2) and abscess at the injection site (n = 1). Conclusion. Complete or partial clot resolution in neonatal thrombosis occurred in both the treated group and nontreated group. Randomized controlled trials are warranted to determine the optimal management in neonatal thrombosis.

引用

页数：5

共 19 条

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