IMMUNOHISTOCHEMICAL DISTRIBUTION OF INTESTINAL 15 KDA PROTEIN IN HUMAN TISSUES

被引：14

作者：

WATANABE, K ^{[1
]}

HOSHI, N ^{[1
]}

TSUURA, Y ^{[1
]}

KANDA, T ^{[1
]}

FUJITA, M ^{[1
]}

FUJII, H ^{[1
]}

ONO, T ^{[1
]}

SUZUKI, T ^{[1
]}

机构：

[1] NIIGATA UNIV, SCH MED, DEPT BIOCHEM, NIIGATA, JAPAN

来源：

ARCHIVES OF HISTOLOGY AND CYTOLOGY | 1995年 / 58卷 / 03期

关键词：

D O I：

10.1679/aohc.58.303

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The distribution of human intestinal 15 kDa protein (I-15P), a new fatty acid-binding protein (FABP), was observed in normal tissues using immunohistochemical techniques. The antiserum against human I-15P intensely reacted with the villous epithelium of the terminal ileum but not with the enterocytes of the crypts. Although the surface epithelium of the stomach and villous epithelium of the duodenum showed weak reactivities, the epithelial cells of the jejunum, proximal ileum, colon and rectum, and also glandular epithelia with intestinal metaplasia of the stomach were not immunostained. The other human tissues examined were negative for anti-human I-15P antibody. Human I-15P thus represents a distinctive, confined tissue distribution different from the other FABPs and is expected to serve as a useful cellular marker of terminal ileal enterocytes.

引用

收藏

页码：303 / 306

页数：4

相关论文

共 23 条

[1] CLONING OF A CDNA-ENCODING RAT INTESTINAL FATTY-ACID BINDING-PROTEIN [J].

ALPERS, DH ;

STRAUSS, AW ;

OCKNER, RK ;

BASS, NM ;

GORDON, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (02) :313-317

[2] IMMUNOHISTOCHEMICAL LOCALIZATION OF A SPECIFIC ILEAL PEPTIDE IN THE PIG [J].

BORGSTROM, A ;

WIDER, M ;

MARKS, W ;

LLOYD, R ;

HERMAN, G ;

VINIK, A .

HISTOCHEMISTRY, 1986, 86 (01) :101-105

[3]

CHAN L, 1985, J BIOL CHEM, V260, P2629

[4] A PHYSICAL-CHEMICAL MODEL FOR CELLULAR UPTAKE OF FATTY-ACIDS - PREDICTION OF INTRACELLULAR POOL SIZES [J].

COOPER, R ;

NOY, N ;

ZAKIM, D .

BIOCHEMISTRY, 1987, 26 (18) :5890-5896

[5] CELL-SPECIFIC IMMUNOHISTOCHEMICAL LOCALIZATION OF A CELLULAR RETINOL-BINDING PROTEIN (TYPE-2) IN THE SMALL-INTESTINE OF RAT [J].

CROW, JA ;

ONG, DE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (14) :4707-4711

[6] EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN PROXIMAL TUBULES OF MOUSE KIDNEY - ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUE [J].

GRAHAM, RC ;

KARNOVSKY, MJ .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1966, 14 (04) :291-+

[7] ONTOGENIC APPEARANCE OF 3 FATTY-ACID BINDING-PROTEINS IN THE RAT STOMACH [J].

ISEKI, S ;

KANDA, T ;

HITOMI, M ;

ONO, T .

ANATOMICAL RECORD, 1991, 229 (01) :51-60

[8] EXPRESSION AND LOCALIZATION OF INTESTINAL 15-KDA PROTEIN IN THE RAT [J].

ISEKI, S ;

AMANO, O ;

KANDA, T ;

FUJII, H ;

ONO, T .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 1993, 123 (1-2) :113-120

[9] PRIMARY STRUCTURE OF A 15-KDA PROTEIN FROM RAT INTESTINAL EPITHELIUM - SEQUENCE SIMILARITY TO FATTY-ACID-BINDING PROTEINS [J].

KANDA, T ;

ODANI, S ;

TOMOI, M ;

MATSUBARA, Y ;

ONO, T .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 197 (03) :759-768

[10] INTRACELLULAR FATTY-ACID TRAFFICKING AND THE ROLE OF CYTOSOLIC LIPID-BINDING PROTEINS [J].

MATARESE, V ;

STONE, RL ;

WAGGONER, DW ;

BERNLOHR, DA .

PROGRESS IN LIPID RESEARCH, 1989, 28 (04) :245-272