ENDOTHELIN ET(A) AND ET(B) RECEPTORS IN SUBARACHNOID HEMORRHAGE-INDUCED CEREBRAL VASOSPASM

被引：42

作者：

ZUCCARELLO, M

LEWIS, AI

RAPOPORT, RM

机构：

[1] UNIV CINCINNATI,COLL MED,DEPT PHARMACOL & CELL BIOPHYS,CINCINNATI,OH 45267

[2] UNIV CINCINNATI,VET AFFAIRS MED CTR,COLL MED,CINCINNATI,OH 45267

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 259卷 / 01期

关键词：

ENDOTHELIN; BASILAR ARTERY; CROMAKALIM;

D O I：

10.1016/0014-2999(94)90167-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The relative roles of endothelin ET(A) and ET(B) receptor activation in cerebral vasospasm following subarachnoid hemorrhage were investigated in the rabbit. The endothelin ET(A) receptor antagonist, BQ610 (1 mu M; homopiperidinyl-CO-Leu-D-Trp(CHO)-D-Trp-OH), and the endothelin ET(A)/ET(B) receptor antagonist, PD145065 (1 mu M; Ac-D-Bhg-L-Leu-L-Asp-L-Ile-L-Ile-L-Trp), relaxed the vasospastic basilar artery in situ by 45% and 87%, respectively. These results suggest that subarachnoid hemorrhage-induced vasospasm of the rabbit basilar artery is due to activation of both endothelin ET(A) and ET(B) receptors.

引用

页码：R1 / R2

页数：2

共 4 条

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[2] CEREBRAL VASOSPASM AND VASOCONSTRICTION CAUSED BY ENDOTHELIN
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[3] PHOSPHORAMIDON PREVENTS CEREBRAL VASOSPASM FOLLOWING SUBARACHNOID HEMORRHAGE IN DOGS - THE RELATIONSHIP TO ENDOTHELIN-1 LEVELS IN THE CEREBROSPINAL-FLUID
MATSUMURA, Y
IKEGAWA, R
SUZUKI, Y
TAKAOKA, M
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KIDO, H
SHINYAMA, H
HAYASHI, K
WATANABE, M
MORIMOTO, S
[J]. LIFE SCIENCES, 1991, 49 (11) : 841 - 848
[4] ZUCCARELLO M, 1993, CEREBRAL VASOSPASM, P229

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