CYCLOADDUCTS OF ETHENE WITH 2(1H)-PYRAZINONES FUNCTIONALIZATION AND REDUCTION TO 2,5-DIAZABICYCLO[2.2.2]OCTAN-3-ONES

被引：11

作者：

LOOSEN, PK ^{[1
]}

KHORASANI, MF ^{[1
]}

TOPPET, SM ^{[1
]}

HOORNAERT, GJ ^{[1
]}

机构：

[1] KATHOLIEKE UNIV LEUVEN,DEPT CHEM,ORGAN SYNTH LAB,CELESTIJNENLAAN 200F,B-3001 LOUVAIN,BELGIUM

来源：

TETRAHEDRON | 1991年 / 47卷 / 44期

关键词：

D O I：

10.1016/S0040-4020(01)96215-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compounds 4 were prepared via Diels-Alder reaction of 3,5-dichloro-2(1H)-pyrazinones 1 with ethene, followed by catalytic reduction of the iminochloride group generated in the cycloadducts 2. Substitution of the iminochloride group with various nucleophiles afforded the 6-functionalised analogues of 2. Their reduction can lead to 6-substituted derivatives of compounds 4. One example is given.

引用

页码：9269 / 9278

页数：10

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