LIPOSOMES FOR THE TRANSFORMATION OF EUKARYOTIC CELLS

被引：98
作者：
HUG, P [1 ]
SLEIGHT, RG [1 ]
机构：
[1] UNIV CINCINNATI, DEPT MOLEC GENET BIOCHEM & MICROBIOL, CINCINNATI, OH 45267 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1097卷 / 01期
关键词：
LIPOSOME; TRANSFECTION; GENE REPLACEMENT THERAPY; DNA; PH-SENSITIVE LIPOSOMES; SMALL UNILAMELLAR LIPOSOMES; VESICULAR STOMATITIS-VIRUS; HIGH-DENSITY LIPOPROTEINS; HVJ SENDAI VIRUS; QUATERNARY AMMONIUM DETERGENT; MEDIATED GENE-TRANSFER; SPHINGOMYELIN-CHOLESTEROL LIPOSOMES; HIGH-EFFICIENCY TRANSFORMATION; CULTURED MAMMALIAN-CELLS;
D O I：
10.1016/0925-4439(91)90016-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Gene therapy of human disease is a method of treatment under active development. DNA-loaded liposomes exhibit great promise for use in this field. Liposome-based transfection vectors have many inherent advantages that will likely lead to their wide in vivo use. Vectors with low toxicity and a high degree of targetability can now be easily prepared. These vectors are also free of the length constraints governing retroviral vectors. In this review we discuss recent developments in the use of liposomes for transfection of eukaryotic cells.
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页码：1 / 17
页数：17
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