EFFECTS OF RIBONUCLEOTIDE REDUCTASE INHIBITION ON PYRIMIDINE DEOXYNUCLEOTIDE METABOLISM IN ACYCLOVIR-TREATED CELLS INFECTED WITH HERPES-SIMPLEX VIRUS TYPE-1

被引：25
作者：
KARLSSON, A
HARMENBERG, J
机构：
[1] NATL BACTERIOL LAB, DEPT VIROL, S-10521 STOCKHOLM, SWEDEN
[2] KAROLINSKA INST, DEPT VIROL, S-10401 STOCKHOLM 60, SWEDEN
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1988年 / 32卷 / 07期
关键词：
D O I：
10.1128/AAC.32.7.1100
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The pyrimidine metabolism of fibroblasts infected with herpes simplex virus type 1 was studied. Herpes simplex virus type 1 infection increased the dTTP pool and thymidylate synthetase activity but reduced thymidine excretion. Addition of acyclovir to infected cells increased thymidine excretion, the dTTP pool, and thymidylate synthetase activity. Addition of a virus-specific ribonucleotide reductase inhibitor (A723U) decreased all three. The synergy between the two compounds is discussed.
引用
收藏
页码：1100 / 1102
页数：3
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