Glucose-responsive neurons in the brainstem

Area Postrema: The influence on feeding behavior caused by ablation of the area postrema (AP) in rodents indicates the participation of this structure in the control of ingestion, Two types of glucose responsive neurons were identified in the AP: one is characterized by increasing the discharge rate in response to glucose (glucoreceptor type) and the other by decreasing the discharge rates in response to glucose (glucose sensitive type), These glucose responsive neurons may participate in glycemic homeostasis. Nucleus of Solitary Tract: The glucose responsive neurons exist within the caudal portion of nucleus of the solitary tract (NTS), a relay station in visceral afferents, Two types similar to the AP were also recognized, It is confirmed that hepatic glucose sensitive afferents terminate on some of the glucose sensitive neurons, This convergence may serve as a fail-safe mechanism, In addition, the NTS involving complex neural networks of excitatory and inhibitory interneurons may be concerned with integration of glycemic information. Dorsal Motor Nucleus of Vagus: Some neurons within the dorsal motor nucleus of the vagus (DMV) were identified as the glucose responsive ones, Both types were also recognized, It is confirmed by antidromic activation that these glucose responsive DMV neurons send their axons toward the gastric or coeliac branch that innervates either the stomach, intestine or pancreas, Some of the DMV neurons may subserve an enteroceptor function by themselves, They may also play a role in the brainstem neural control of glycemic homeostasis as the failsafe mechanism.