EFFECT OF S-TRIAZINE COMPOUNDS ON TESTOSTERONE-METABOLISM IN THE RAT PROSTATE

被引：42

作者：

KNIEWALD, J ^{[1
]}

OSREDECKI, V ^{[1
]}

GOJMERAC, T ^{[1
]}

ZECHNER, V ^{[1
]}

KNIEWALD, Z ^{[1
]}

机构：

[1] VET INST,ZAGREB,CROATIA

来源：

JOURNAL OF APPLIED TOXICOLOGY | 1995年 / 15卷 / 03期

关键词：

ATRAZINE; PROMETRYNE; RAT; PROSTATE; TESTOSTERONE METABOLISM; 5-ALPHA-DIHYDROTESTOSTERONE-RECEPTOR COMPLEX;

D O I：

10.1002/jat.2550150312

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The influence of s-triazine compounds (atrazine, prometryne and deethylatrazine) on testosterone conversion and 5 alpha-dihydrotestosterone-receptor complex formation was studied in vitro and in vivo in the rat prostate. A marked in vitro influence of atrazine and prometryne (from 0.465 to 1.392 mu mol) and their mixtures (in total concentration, 0.928 mu mol) on 5 alpha-dihydrotestosterone formation was detected, 5 alpha-Dihydrotestosterone-specific receptor complex formation was inhibited in vitro by ca. 0.5 mu mol of atrazine or deethylatrazine and only in vivo by 6 mg of atrazine 100 g(-1) body wt. daily during 7 days in the prostate cytosol. The inhibition of the enzymic activities responsible for testosterone conversion and steroid hormone-receptor complex formation was non-competitive and reversible, and s-triazine compounds act as antiandrogens.

引用

页码：215 / 218

页数：4

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