MAPPING OF HUMAN INTER-ALPHA-TRYPSIN INHIBITOR FAMILY HEAVY CHAIN-RELATED PROTEIN GENE (ITIHL1) TO HUMAN-CHROMOSOME 3P21-]P14

被引：12

作者：

TOBE, T ^{[1
]}

SAGUCHI, K ^{[1
]}

HASHIMOTO, K ^{[1
]}

MIURA, NH ^{[1
]}

TOMITA, M ^{[1
]}

LI, F ^{[1
]}

WANG, Y ^{[1
]}

MINOSHIMA, S ^{[1
]}

SHIMIZU, N ^{[1
]}

机构：

[1] KEIO UNIV,SCH MED,DEPT MOLEC BIOL,TOKYO,JAPAN

来源：

CYTOGENETICS AND CELL GENETICS | 1995年 / 71卷 / 03期

关键词：

D O I：

10.1159/000134130

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) is a novel glycoprotein isolated from human plasma. The cDNA encoding IHRP has recently been cloned from human liver cDNA Libraries. We report the mapping of this gene (ITIHL1) by fluorescence in situ hybridization using a 2.5-kb cDNA fragment as a probe. ITIHL1 was localized to chromosome region 3p21 --> p14 where the genes of heavy chain 1 and 3 of inter-alpha-trypsin inhibitor are located. This result, together with significant homology between the nucleotide sequences of ITIHL1 and the heavy chain genes, supports ITIHL1 as being a member of an evolutionary related gene family of ITI heavy chains. Northern blot analysis indicated that IHRP was predominantly synthesized in liver. From Southern blot analysis, it was tentatively concluded that ITIHL1 is a single copy gene.

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收藏

页码：296 / 298

页数：3

相关论文

共 47 条

[41] Mapping of a new MAP kinase activated protein kinase gene (3PK) to human chromosome band 3p21.2 and ordering of 3PK and two cosmid markers in the 3p22-p21 tumour-suppressor region by two-colour fluorescence in situ hybridization [J].

Szeles, A ;

BajalicaLagercrantz, S ;

Lindblom, A ;

Lushnikova, T ;

Kashuba, VI ;

Imreh, S ;

Nordenskjold, M ;

Klein, G ;

Zabarovsky, ER .

CHROMOSOME RESEARCH, 1996, 4 (04) :310-313

[42] The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3 [J].

Stavros Malas ;

Sarah Duthie ;

Panagiotis Deloukas ;

Vasso Episkopou .

Mammalian Genome, 1999, 10 :934-937

[43] The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3 [J].

Malas, S ;

Duthie, S ;

Deloukas, P ;

Episkopou, V .

MAMMALIAN GENOME, 1999, 10 (09) :934-937

[44] CHROMOSOMAL MAPPING OF MEMBERS OF THE CDC2 FAMILY OF PROTEIN-KINASES, CDK3 CDK6, PISSLRE, AND PITALRE, AND A CDK INHIBITOR, P27(KIP1), TO REGIONS INVOLVED IN HUMAN CANCER [J].

BULLRICH, F ;

MACLACHLAN, TK ;

SANG, NL ;

DRUCK, T ;

VERONESE, ML ;

ALLEN, SL ;

CHIORAZZI, N ;

KOFF, A ;

HEUBNER, K ;

CROCE, CM ;

GIORDANO, A .

CANCER RESEARCH, 1995, 55 (06) :1199-1205

[45] ASSIGNMENT OF AN INTRON-CONTAINING HUMAN HEAT-SHOCK PROTEIN GENE (HSP90-BETA, HSPCB) TO CHROMOSOME-6 NEAR TCTE1 (6P21) AND 2 INTRONLESS PSEUDOGENES TO CHROMOSOME-4 AND CHROMOSOME-15 BY POLYMERASE CHAIN-REACTION AMPLIFICATION FROM A PANEL OF HYBRID CELL-LINES [J].

DURKIN, AS ;

MAGLOTT, DR ;

VAMVAKOPOULOS, NC ;

ZOGHBI, HY ;

NIERMAN, WC .

GENOMICS, 1993, 18 (02) :452-454

[46] Chromosomal mapping of a family of human glutamine synthetase genes: Functional gene (GLUL) on 1q25, pseudogene (GLULP) on 9p13, and three related genes (GLULL1, GLULL2, GLULL3) on 5q33, 11p15, and 11q24 [J].

Wang, YM ;

Kudoh, J ;

Kubota, R ;

Asakawa, S ;

Minoshima, S ;

Shimizu, N .

GENOMICS, 1996, 37 (02) :195-199

[47] Assignment of human protein phosphatase 2A regulatory subunit genes B56 alpha, B56 beta, B56 gamma, B56 delta, and B56 epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2->p12 [J].

McCright, B ;

Brothman, AR ;

Virshup, DM .

GENOMICS, 1996, 36 (01) :168-170

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