MAPPING OF HUMAN INTER-ALPHA-TRYPSIN INHIBITOR FAMILY HEAVY CHAIN-RELATED PROTEIN GENE (ITIHL1) TO HUMAN-CHROMOSOME 3P21-]P14

被引：12

作者：

TOBE, T ^{[1
]}

SAGUCHI, K ^{[1
]}

HASHIMOTO, K ^{[1
]}

MIURA, NH ^{[1
]}

TOMITA, M ^{[1
]}

LI, F ^{[1
]}

WANG, Y ^{[1
]}

MINOSHIMA, S ^{[1
]}

SHIMIZU, N ^{[1
]}

机构：

[1] KEIO UNIV,SCH MED,DEPT MOLEC BIOL,TOKYO,JAPAN

来源：

CYTOGENETICS AND CELL GENETICS | 1995年 / 71卷 / 03期

关键词：

D O I：

10.1159/000134130

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) is a novel glycoprotein isolated from human plasma. The cDNA encoding IHRP has recently been cloned from human liver cDNA Libraries. We report the mapping of this gene (ITIHL1) by fluorescence in situ hybridization using a 2.5-kb cDNA fragment as a probe. ITIHL1 was localized to chromosome region 3p21 --> p14 where the genes of heavy chain 1 and 3 of inter-alpha-trypsin inhibitor are located. This result, together with significant homology between the nucleotide sequences of ITIHL1 and the heavy chain genes, supports ITIHL1 as being a member of an evolutionary related gene family of ITI heavy chains. Northern blot analysis indicated that IHRP was predominantly synthesized in liver. From Southern blot analysis, it was tentatively concluded that ITIHL1 is a single copy gene.

引用

收藏

页码：296 / 298

页数：3

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