A NEW ALPHA-CHAIN VARIANT, HB TURRIFF [ALPHA-99(G6)LYS-]GLU] - THE INTERFERENCE OF ABNORMAL-HEMOGLOBINS IN HB A1C DETERMINATION

被引：22

作者：

LANGDOWN, JV

DAVIDSON, RJL

WILLIAMSON, D

机构：

[1] UNIV CAMBRIDGE,CTR MRC,DEPT HAEMATOL,CAMBRIDGE CB2 2QH,ENGLAND

[2] ABERDEEN ROYAL INFIRM,DEPT HAEMATOL,ABERDEEN AB9 2ZB,SCOTLAND

来源：

HEMOGLOBIN | 1992年 / 16卷 / 1-2期

基金：

英国惠康基金;

关键词：

D O I：

10.3109/03630269209005671

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hb Turriff is a new hemoglobin variant which we have identified in a diabetic individual. During the determination of Hb A1c by high performance liquid chromatography, an inappropriately elevated result was found to be due to the abnormal hemoglobin chromatographing with the Hb A1c fraction. This new hemoglobin variant, Hb Turriff [alpha-99(G6)Lys --> Glu], is not associated with any hematological disturbance, and family investigations indicate that it has arisen as a de novo mutation.

引用

页码：11 / 17

页数：7

共 8 条

[1]

BASSET P, 1978, BLOOD, V51, P971

[2] ESTIMATION OF SMALL PERCENTAGES OF FOETAL HAEMOGLOBIN [J].