8-HYDROXYDEOXYGUANOSINE IN DNA INHIBITS RESTRICTION ENDONUCLEASE DIGESTION

被引：9
|
作者：
JONES, DS [1 ]
NEMOTO, F [1 ]
KUCHINO, Y [1 ]
OHTSUKA, E [1 ]
NISHIMURA, S [1 ]
机构：
[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,SAPPORO,HOKKAIDO 060,JAPAN
来源：
NUCLEOSIDES & NUCLEOTIDES | 1990年 / 9卷 / 02期
关键词：
D O I：
10.1080/07328319008045134
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A DNA fragment containing 8-hydroxydeoxyguanosine wasused to prime second strand synthesis of a recombinant pTZ19 phagemid single stranded DNA. The resultant double stranded closed circular product and also the annealed product of the single stranded DNA and the fragment were found to be resistant to cleavage by the restriction enzyme ApaLI in whose recognition sequence the 8-hydroxydeoxyguanosine had been inserted. © 1990, Taylor & Francis Group, LLC. All rights reserved.
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收藏
页码：223 / 233
页数：11
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