INDUCTION OF RAPID EYE-MOVEMENT SLEEP BY CARBACHOL INFUSION INTO THE PONTINE RETICULAR-FORMATION IN THE RAT

被引：129

作者：

BOURGIN, P ^{[1
]}

ESCOURROU, P ^{[1
]}

GAULTIER, C ^{[1
]}

ADRIEN, J ^{[1
]}

机构：

[1] CHU KREMLIN BICETRE,DEPT PHYSIOL,LE KREMLIN BICETR,FRANCE

来源：

NEUROREPORT | 1995年 / 6卷 / 03期

关键词：

REM SLEEP; WAKEFULNESS; CARBACHOL; MUSCARINIC RECEPTORS; PONTINE RETICULAR NUCLEUS ORALIS; ACETYLCHOLINE;

D O I：

10.1097/00001756-199502000-00031

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

CHOLINERGIC regulation of sleep and wakefulness was studied in freely moving rats locally infused with various doses of carbachol into the pontine reticular formation. Induction of REM sleep occurred when carbachol was infused specifically into the posterior oral pontine reticular nucleus (PnO). This effect was observed with 1-10 ng of carbachol, and lasted for at least 6 h. It was antagonized by atropine (100-200 ng) infused into the same site 15 min before carbachol (10 ng), indicating that REM sleep induction resulted from the stimulation of pontine muscarinic receptors. High doses of carbachol (500 ng) did not affect REM sleep but enhanced wakefulness. Cholinergic mechanisms within the PnO may play a critical role in the regulation of REM sleep in the rat.

引用

页码：532 / 536

页数：5

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