MEASUREMENT OF BRAIN PHOSPHOINOSITIDE METABOLISM IN BIPOLAR PATIENTS USING INVIVO P-31-MRS

被引：83

作者：

KATO, T ^{[1
]}

SHIORI, T ^{[1
]}

TAKAHASHI, S ^{[1
]}

INUBUSHI, T ^{[1
]}

机构：

[1] SHIGA UNIV MED SCI,MOLEC NEUROBIOL RES CTR,OTSU,SHIGA 52021,JAPAN

来源：

JOURNAL OF AFFECTIVE DISORDERS | 1991年 / 22卷 / 04期

关键词：

BIPOLAR AFFECTIVE DISORDER; MAGNETIC RESONANCE SPECTROSCOPY; LITHIUM; INOSITOL PHOSPHATE; PHOSPHOINOSITIDE;

D O I：

10.1016/0165-0327(91)90064-Y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In vivo phosphorus-31 magnetic resonance spectroscopy (P-31-MRS) was used to measure phosphorus metabolism in the brains of manic patients treated with lithium carbonate. The phosphomonoester (PME) peak was elevated in the manic state in patients with DSM-IIIR bipolar disorder compared to the euthymic state and to drug-free normal controls. Elevation of the PME peak may be caused by lithium-induced accumulation of inositol 1-phosphate in the brain.

引用

页码：185 / 190

页数：6

共 19 条

[1] INCREASED BRAIN MYOINOSITOL 1-PHOSPHATE IN LITHIUM-TREATED RATS [J].

ALLISON, JH ;

BLISNER, ME ;

HOLLAND, WH ;

HIPPS, PP ;

SHERMAN, WR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 71 (02) :664-670

[2] LITHIUM AMPLIFIES AGONIST-DEPENDENT PHOSPHATIDYLINOSITOL RESPONSES IN BRAIN AND SALIVARY-GLANDS [J].

BERRIDGE, MJ ;

DOWNES, CP ;

HANLEY, MR .

BIOCHEMICAL JOURNAL, 1982, 206 (03) :587-595

[3] DEPTH-RESOLVED SURFACE-COIL SPECTROSCOPY (DRESS) FOR INVIVO H-1, P-31, AND C-13 NMR [J].

BOTTOMLEY, PA ;

FOSTER, TB ;

DARROW, RD .

JOURNAL OF MAGNETIC RESONANCE, 1984, 59 (02) :338-342

[4]

BOTTOMLEY PA, 1989, RADIOLOGY, V170, P1

[5] INVIVO P-31 NMR PROFILES OF ALZHEIMERS-DISEASE AND MULTIPLE SUBCORTICAL INFARCT DEMENTIA [J].

BROWN, GG ;

LEVINE, SR ;

GORELL, JM ;

PETTEGREW, JW ;

GDOWSKI, JW ;

BUERI, JA ;

HELPERN, JA ;

WELCH, KMA .

NEUROLOGY, 1989, 39 (11) :1423-1427

[6]

CADY EB, 1983, LANCET, V1, P1059

[7] RESOLUTION ENHANCEMENT OF PROTEIN PMR SPECTRA USING DIFFERENCE BETWEEN A BROADENED AND A NORMAL SPECTRUM [J].

CAMPBELL, ID ;

DOBSON, CM ;

WILLIAMS, RJP ;

XAVIER, AV .

JOURNAL OF MAGNETIC RESONANCE, 1973, 11 (02) :172-181

[8] RETENTION AND DISTRIBUTION PATTERNS OF LITHIUM A PHARMACOLOGICAL TOOL IN STUDYING PATHOPHYSIOLOGY OF MANIC-DEPRESSIVE PSYCHOSIS [J].

GREENSPAN, K ;

GREEN, R ;

DURELL, J .

AMERICAN JOURNAL OF PSYCHIATRY, 1968, 125 (04) :512-+

[9] PHOSPHORYLETHANOLAMINE - THE MAJOR CONSTITUENT OF THE PHOSPHOMONOESTER PEAK OBSERVED BY P-31-NMR ON DEVELOPING DOG BRAIN [J].

GYULAI, L ;

BOLINGER, L ;

LEIGH, JS ;

BARLOW, C ;

CHANCE, B .

FEBS LETTERS, 1984, 178 (01) :137-142

[10]

HALLCHER LM, 1980, J BIOL CHEM, V255, P896

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