IMIDAZO[1,2-B]PYRIDAZINES .9. SYNTHESES AND CENTRAL-NERVOUS-SYSTEM ACTIVITIES OF SOME 3-ALKOXY-6-(ORTHO-ALKOXY-PHENOXY, ORTHO-METHYLTHIO-PHENOXY OR ORTHO-FLUORO-PHENOXY)-2-ARYLIMIDAZO[1,2-B]PYRIDAZINES

被引：8

作者：

BARLIN, GB ^{[1
]}

DAVIES, LP ^{[1
]}

IRELAND, SJ ^{[1
]}

KHOO, CLY ^{[1
]}

NGUYEN, TMT ^{[1
]}

机构：

[1] AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,RES SCH BIOL SCI,VISUAL SCI GRP,CANBERRA,ACT 2601,AUSTRALIA

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1990年 / 43卷 / 03期

关键词：

D O I：

10.1071/CH9900503

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Syntheses are reported for a series of 6-(o-methoxy-, o-ethoxy-, o-methylthio- and o-fluoro- phenoxy)-3-(methoxy and ethoxy)-2-phenyl(substituted phenyl and pyridin-3″-yl)imidazo[l, 2- b]pyridazines. 1C50 values are reported for the displacement of 3H-diazepam from rat brain membrane by each of these compounds. The most active compounds were found to be 3-ethoxy-2-(p-fluorophenyl)-6-(o-methoxyphen- oxy)-, 3-methoxy-6-(o-methoxyphenoxy)-2-(m-nitrophenyl) and 3-methoxy-6-(o-methoxyphen- oxy)-2-(3″, 4″-methylenedioxy)imidazo[l, 2-b]pyridazines with 1C50 values of 15, 18 and 19 nM respectively. © 1990 ASEG.

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页码：503 / 510

页数：8

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