Purpose: To report the early postoperative outcomes of perfluorohexyloctane/ silicone oil solution (Densiron-68) as an ocular endotamponade in the management of complicated retinal detachments involving the inferior quadrants. Methods: In this, prospective study, we evaluated 19 eyes of 18 patients who had complicated retinal detachment involving the inferior quadrants with proliferative vitreoretinopathy (PVR) grade C or worse. Densiron-68 was used in all eyes as an ocular endotamponade. Main outcome measures were anatomic and visual outcomes, and postoperative complications. Results: Mean follow-up time after Densiron-68 removal was 5.1 months (1-12 months). Single operation success rate was achieved in 10 of 19 eyes (% 52.6). Retina was reattached in 16 of 19 eyes (% 84.2) after additional procedures. Preoperative visual acuity was between hand movements and 6/10 (Median: hand movements); while, postoperative visual acuity was between hand movements and 6/10 (Median: counting fingers at 1 meter). Postoperative visual acuity improved in 10 eyes (53%), remained stable in 8 eyes (42%), and decreased in I eye (5%). Postoperative complications were cataract formation in all of 5 phakic eyes (100%), transient increase of intraocular pressure controlled by topical antiglaucomatous medications in 5 eyes (26%), inflammatory reaction in the anterior chamber in 4 eyes (21%), macular pucker development in 2 eyes (10%), secondary glaucoma controlled by topical antiglaucomatous medications in 2 eyes (10%), and passage of silicone oil into the anterior chamber in 1 eye (5%). Conclusion: Densiron-68 appears to be useful as an intraocular tamponade in the management of complicated retinal detachments involving the inferior quadrants. However, further studies comparing Densiron-68 with standard silicone oil with a large number of patients and a longer follow-up are required.