CHROMATIN ORGANIZATION RE-VIEWED

被引：102

作者：

WOODCOCK, CL ^{[1
]}

HOROWITZ, RA ^{[1
]}

机构：

[1] UNIV MASSACHUSETTS,PROGRAM MOLEC & CELLULAR BIOL,AMHERST,MA 01003

来源：

TRENDS IN CELL BIOLOGY | 1995年 / 5卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0962-8924(00)89038-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The predominant view of chromatin structure is that the headed chain of nucleosomes is folded into a symmetrical helical fibre. Recently, however, direct evidence from cryoelectron microscopy and other imaging techniques confirms a non-symmetrical organization, consistent with modelling based on the heterogeneity of linker DNA lengths. This mode of chromatin folding is more compatible with the range of functional states in the living nucleus.

引用

页码：272 / 277

页数：6

共 52 条

[1] ORGANIZATION OF CHROMOSOMES IN MITOTIC HELA-CELLS [J].

ADOLPH, KW .

EXPERIMENTAL CELL RESEARCH, 1980, 125 (01) :95-103

[2] ATOMIC-FORCE MICROSCOPE MEASUREMENTS OF NUCLEOSOME CORES ASSEMBLED ALONG DEFINED DNA-SEQUENCES [J].

ALLEN, MJ ;

DONG, XF ;

ONEILL, TE ;

YAU, P ;

KOWALCZYKOWSKI, SC ;

GATEWOOD, J ;

BALHORN, R ;

BRADBURY, EM .

BIOCHEMISTRY, 1993, 32 (33) :8390-8396

[3]

[Anonymous], 1994, MOL BIOL CELL

[4] THE DIAMETERS OF FROZEN-HYDRATED CHROMATIN FIBERS INCREASE WITH DNA LINKER LENGTH - EVIDENCE IN SUPPORT OF VARIABLE DIAMETER MODELS FOR CHROMATIN [J].

ATHEY, BD ;

SMITH, MF ;

RANKERT, DA ;

WILLIAMS, SP ;

LANGMORE, JP .

JOURNAL OF CELL BIOLOGY, 1990, 111 (03) :795-806

[5]

BAHR GF, 1977, MOL STRUCTURE HUMAN, P143

[6] LARGE-SCALE CHROMATIN STRUCTURAL DOMAINS WITHIN MITOTIC AND INTERPHASE CHROMOSOMES INVIVO AND INVITRO [J].

BELMONT, AS ;

BRAUNFELD, MB ;

SEDAT, JW ;

AGARD, DA .

CHROMOSOMA, 1989, 98 (02) :129-143

[7] THE SUPERSTRUCTURE OF CHROMATIN AND ITS CONDENSATION MECHANISM .2. THEORETICAL-ANALYSIS OF THE X-RAY-SCATTERING PATTERNS AND MODEL-CALCULATIONS [J].

BORDAS, J ;

PEREZGRAU, L ;

KOCH, MHJ ;

VEGA, MC ;

NAVE, C .

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 1986, 13 (03) :175-185

[8] Role of chromatin structure in the regulation of transcription by RNA polymerase II [J].

Croston, Glenn E. ;

Kadonaga, James T. .

CURRENT OPINION IN CELL BIOLOGY, 1993, 5 (03) :417-423

[9] CRYO-ELECTRON MICROSCOPY OF VITRIFIED SPECIMENS [J].

DUBOCHET, J ;

ADRIAN, M ;

CHANG, JJ ;

HOMO, JC ;

LEPAULT, J ;

MCDOWALL, AW ;

SCHULTZ, P .

QUARTERLY REVIEWS OF BIOPHYSICS, 1988, 21 (02) :129-228

[10]

DuPraw E.J, 1970, DNA CHROMOSOMES

← 1 2 3 4 5 6 →