THE GLYCINE NMDA RECEPTOR ANTAGONIST, L-701,324 REVERSES ISOLATION-INDUCED DEFICITS IN PREPULSE INHIBITION IN THE RAT

被引：58
|
作者：
BRISTOW, LJ
LANDON, L
SAYWELL, KL
TRICKLEBANK, MD
机构：
[1] Merck, Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, CM20 2QR, Essex, Terlings Park, Eastwick Road
来源：
PSYCHOPHARMACOLOGY | 1995年 / 118卷 / 02期
关键词：
PREPULSE INHIBITION; ACOUSTIC STARTLE; SOCIAL ISOLATION; GLYCINE NMDA RECEPTOR; L-701,324; DOPAMINERGIC HYPERACTIVITY;
D O I：
10.1007/BF02245847
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Previous studies have demonstrated that the glycine/NMDA receptor antagonist, L-701,324 (7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)quinolone) blocks the activation of mesolimbic dopamine systems induced following psychostimulant administration in the rat (Bristow et al. 1994). In the present study, pretreatment with L-701,324 also reversed the deficit in prepulse inhibition (PPI) observed in rats reared in social isolation after weaning. Given that PPI is also attenuated in schizophrenic patients and that isolation rearing induces both neurochemical and behavioural abnormalities suggestive of a physiologically induced state of dopaminergic hyperactivity, these results suggest that blockade of the glycine/NMDA receptor may offer a new strategy for the development of novel antipsychotic agents.
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收藏
页码：230 / 232
页数：3
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