14-3-3-PROTEIN HOMOLOGS REQUIRED FOR THE DNA-DAMAGE CHECKPOINT IN FISSION YEAST

被引：322

作者：

FORD, JC ^{[1
]}

ALKHODAIRY, F ^{[1
]}

FOTOU, E ^{[1
]}

SHELDRICK, KS ^{[1
]}

GRIFFITHS, DJF ^{[1
]}

CARR, AM ^{[1
]}

机构：

[1] UNIV SUSSEX,MRC,CELL MUTAT UNIT,BRIGHTON BN1 9RR,ENGLAND

来源：

SCIENCE | 1994年 / 265卷 / 5171期

关键词：

D O I：

10.1126/science.8036497

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During the cell cycle, DNA is replicated and segregated equally into two daughter cells. The DNA damage checkpoint ensures that DNA damage is repaired before mitosis is attempted. Genetic studies of the fission yeast Schizosaccharomyces pombe have identified two genes, rad24 and rad25, that are required for this checkpoint. These genes encode 14-3-3 protein homologs that together provide a function that is essential for cell proliferation. In addition, S. pombe rad24 null mutants, and to a lesser extent rad25 null mutants, enter mitosis prematurely, which indicates that 14-3-3 proteins have a role in determining the timing of mitosis.

引用

页码：533 / 535

页数：3

共 23 条

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