THE RETINOID-X RECEPTOR-LIGAND, 9-CIS-RETINOIC ACID, IS A POTENTIAL REGULATOR OF EARLY XENOPUS DEVELOPMENT

被引：76

作者：

KRAFT, JC ^{[1
]}

SCHUH, T ^{[1
]}

JUCHAU, M ^{[1
]}

KIMELMAN, D ^{[1
]}

机构：

[1] UNIV WASHINGTON,SCH MED,DEPT BIOCHEM SJ-70,SEATTLE,WA 98195

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 08期

关键词：

D O I：

10.1073/pnas.91.8.3067

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Endogenous retinoids are potential regulators of vertebrate embryogenesis that have been implicated in early anterior-posterior patterning and limb-bud development. We have characterized the temporal and spatial distribution of 9-cis-retinoic acid in the Xenopus embryo and compared it to two other retinoids, all-trans-retinoic acid and all-trans-retinoyl-beta-glucuronide. 9-cis-Retinoic acid is first detected after the midblastula transition and by the end of gastrulation is localized primarily within the anterior and posterior dorsal regions of the embryo. Since 9-cis-retinoic acid is a 6-fold more potent dysmorphogen than trans-retinoic acid, we suggest that it is involved in the early specification of the Xenopus anterior-posterior axis.

引用

页码：3067 / 3071

页数：5

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