THE RETINOID-X RECEPTOR-LIGAND, 9-CIS-RETINOIC ACID, IS A POTENTIAL REGULATOR OF EARLY XENOPUS DEVELOPMENT

被引：76
|
作者：
KRAFT, JC [1 ]
SCHUH, T [1 ]
JUCHAU, M [1 ]
KIMELMAN, D [1 ]
机构：
[1] UNIV WASHINGTON,SCH MED,DEPT BIOCHEM SJ-70,SEATTLE,WA 98195
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 08期
关键词：
D O I：
10.1073/pnas.91.8.3067
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Endogenous retinoids are potential regulators of vertebrate embryogenesis that have been implicated in early anterior-posterior patterning and limb-bud development. We have characterized the temporal and spatial distribution of 9-cis-retinoic acid in the Xenopus embryo and compared it to two other retinoids, all-trans-retinoic acid and all-trans-retinoyl-beta-glucuronide. 9-cis-Retinoic acid is first detected after the midblastula transition and by the end of gastrulation is localized primarily within the anterior and posterior dorsal regions of the embryo. Since 9-cis-retinoic acid is a 6-fold more potent dysmorphogen than trans-retinoic acid, we suggest that it is involved in the early specification of the Xenopus anterior-posterior axis.
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页码：3067 / 3071
页数：5
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