Delivering drugs into the brain: barriers and possibilities

被引:10
作者
Habgood, Mark [1 ]
Ek, Joakim [1 ]
机构
[1] Univ Melbourne, Dept Pharmacol, Parkville, Vic 3010, Australia
关键词
blood-brain barrier; drug efflux; lipid solubility; ABC transporters;
D O I
10.4155/TDE.10.58
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Selectively delivering a therapeutic compound into the brain will require finding solutions to a series of sequential problems.
引用
收藏
页码:483 / 488
页数:6
相关论文
共 51 条
[1]   The factors that influence permeation across the blood-brain barrier [J].
Abraham, MH .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2004, 39 (03) :235-240
[2]   LONG-CIRCULATING (STERICALLY STABILIZED) LIPOSOMES FOR TARGETED DRUG-DELIVERY [J].
ALLEN, TM .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1994, 15 (07) :215-220
[3]   Brain targeting using novel lipid nanovectors [J].
Beduneau, Arnaud ;
Hindre, Francois ;
Clavreul, Anne ;
Leroux, Jean-Christophe ;
Saulnier, Patrick ;
Benoit, Jean-Pierre .
JOURNAL OF CONTROLLED RELEASE, 2008, 126 (01) :44-49
[4]   Active targeting of brain tumors using nanocarriers [J].
Beduneau, Arnaud ;
Saulnier, Patrick ;
Benoit, Jean-Pierre .
BIOMATERIALS, 2007, 28 (33) :4947-4967
[5]   Design of targeted lipid nanocapsules by conjugation of whole antibodies and antibody Fab' fragments [J].
Beduneau, Arnaud ;
Saulnier, Patrick ;
Hindre, Francois ;
Clavreul, Anne ;
Leroux, Jean-Christophe ;
Benoit, Jean-Pierre .
BIOMATERIALS, 2007, 28 (33) :4978-4990
[6]   JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN VERTEBRATE BRAIN [J].
BRIGHTMA.MW ;
REESE, TS .
JOURNAL OF CELL BIOLOGY, 1969, 40 (03) :648-+
[7]   The pathobiology of moderate diffuse traumatic brain injury as identified using a new experimental model of injury in rats [J].
Cernak, I ;
Vink, R ;
Zapple, DN ;
Cruz, MI ;
Ahmed, F ;
Chang, T ;
Fricke, ST ;
Faden, AI .
NEUROBIOLOGY OF DISEASE, 2004, 17 (01) :29-43
[8]  
COLE SPC, 1994, CANCER RES, V54, P5902
[9]   COMPARISON OF LIPID-MEDIATED BLOOD-BRAIN-BARRIER PENETRABILITY IN NEONATES AND ADULTS [J].
CORNFORD, EM ;
BRAUN, LD ;
OLDENDORF, WH ;
HILL, MA .
AMERICAN JOURNAL OF PHYSIOLOGY, 1982, 243 (03) :C161-C168
[10]   A multidrug resistance transporter from human MCF-7 breast cancer cells [J].
Doyle, LA ;
Yang, WD ;
Abruzzo, LV ;
Krogmann, T ;
Gao, YM ;
Rishi, AK ;
Ross, DD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15665-15670