TRANSITION-PROBABILITY MODEL AND REGULATION OF PROLIFERATION OF HUMAN DIPLOID CELL-CULTURES DURING AGING

被引：26

作者：

GROVE, GL ^{[1
]}

CRISTOFALO, VJ ^{[1
]}

机构：

[1] UNIV PENN WISTAR INST ANAT & BIOL, PHILADELPHIA, PA 19104 USA

来源：

CELL AND TISSUE KINETICS | 1976年 / 9卷 / 04期

关键词：

D O I：

10.1111/j.1365-2184.1976.tb01288.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genealogies derived from time-lapse cinemicrophotographic studies of aging human diploid cell cultures were analyzed in terms of the transition probability model. The distribution of intermitotic times obtained from middle passage cells deviated only slightly from that predicted by the model. In contrast, the plot for late passage cultures did not fit the predicted pattern and appeared to be composed of multiple curves. These changes are discussed in reference to cellular senescence as expressed by normal human diploid cells in vitro.

引用

页码：395 / 399

页数：5

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