The emerging role of interleukin-21 in allergic diseases (Review)

被引：17
作者：
Gong, Fang [1 ]
Su, Qiang [2 ,3 ]
Pan, Yu Hong [1 ]
Huang, Xuan [1 ]
Shen, Wei Hong [1 ]
机构：
[1] Nantong Univ, Hosp 3, Dept Lab Med, 585 North Xingyuan Rd, Wuxi 214041, Jiangsu, Peoples R China
[2] Nantong Univ, Hosp 3, Dept Pulm Med, Wuxi 214041, Jiangsu, Peoples R China
[3] Nantong Univ, Hosp 3, Dept Allergy & Clin Immunol, Wuxi 214041, Jiangsu, Peoples R China
来源：
BIOMEDICAL REPORTS | 2013年 / 1卷 / 06期
关键词：
interleukin-21; atopic dermatitis; allergic rhinitis; atopic asthma;
D O I：
10.3892/br.2013.166
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Interleukin ( IL)-21 is a newly discovered member of the type I cytokine family. Since its discovery in 2000, IL-21 has been the focus of extensive investigation, due to its homology to IL-2, IL-4 and IL-15 and its pleiotropic effects on innate and adaptive immune responses. An increasing amount of experimental evidence supports a role for IL-21 in the pathogenesis of several allergic diseases, such as allergic rhinitis, atopic dermatitis (AD) and atopic asthma. In this review, we aimed to discuss the biological characteristics of IL-21 and summarize the current progress on the role of IL-21 in the regulation of allergic inflammation.
引用
收藏
页码：837 / 839
页数：3
相关论文
共 22 条
[11]   IL-21 R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice [J].
Jin, Haoli ;
Oyoshi, Michiko K. ;
Le, Yi ;
Bianchi, Teresa ;
Koduru, Suresh ;
Mathias, Clinton B. ;
Kumar, Lalit ;
Le Bras, Severine ;
Young, Deborah ;
Collins, Mary ;
Grusby, Michael J. ;
Wenzel, Joerg ;
Bieber, Thomas ;
Boes, Marianne ;
Silberstein, Leslie E. ;
Oettgen, Hans C. ;
Geha, Raif S. .
JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (01) :47-60
[12]   Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or bim-dependent apoptosis [J].
Jin, HL ;
Carrio, R ;
Yu, AX ;
Malek, TR .
JOURNAL OF IMMUNOLOGY, 2004, 173 (01) :657-665
[13]   IL-21 induces inhibitor of differentiation 2 and leads to complete abrogation of anaphylaxis in mice [J].
Kishida, Tsunao ;
Hiromura, Yayoi ;
Shin-Ya, Masaharu ;
Asada, Hidetsugu ;
Kuriyama, Hiroko ;
Sugai, Manabu ;
Shimizu, Akira ;
Yokota, Yoshifumi ;
Hama, Takemitsu ;
Imanishi, Jiro ;
Hisa, Yasuo ;
Mazda, Osam .
JOURNAL OF IMMUNOLOGY, 2007, 179 (12) :8554-8561
[14]   Decrease in interleukin-21 in children suffering with severe atopic dermatitis [J].
Lin, Sheng-Chieh ;
Chuang, Ya-Hui ;
Yang, Yao-Hsu ;
Chiang, Bor-Luen .
PEDIATRIC ALLERGY AND IMMUNOLOGY, 2011, 22 (08) :869-875
[15]   IL-21 induces the apoptosis of resting and activated primary B cells [J].
Mehta, DS ;
Wurster, AL ;
Whitters, MJ ;
Young, DA ;
Collins, M ;
Grusby, MJ .
JOURNAL OF IMMUNOLOGY, 2003, 170 (08) :4111-4118
[16]   A critical role for IL-21 in regulating immunoglobulin production [J].
Ozaki, K ;
Spolski, R ;
Feng, CG ;
Qi, CF ;
Cheng, J ;
Sher, A ;
Morse, HC ;
Liu, CY ;
Schwartzberg, PL ;
Leonard, WJ .
SCIENCE, 2002, 298 (5598) :1630-1634
[17]  
Sarra Massimiliano, 2012, Inflammation & Allergy Drug Targets, V11, P313
[18]   Allergic rhinitis [J].
Peter Small ;
Harold Kim .
Allergy, Asthma & Clinical Immunology, 7 (Suppl 1)
[19]   Interleukin-21: Basic biology and implications for cancer and autoimmunity [J].
Spolski, Rosanne ;
Leonard, Warren J. .
ANNUAL REVIEW OF IMMUNOLOGY, 2008, 26 :57-79
[20]   Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line Cε transcription of IL-4-stimulated B cells [J].
Suto, A ;
Nakajima, H ;
Hirose, K ;
Suzuki, K ;
Kagami, S ;
Seto, Y ;
Hoshimoto, A ;
Saito, Y ;
Foster, DC ;
Iwamoto, I .
BLOOD, 2002, 100 (13) :4565-4573
123