The emerging role of interleukin-21 in allergic diseases (Review)

被引：17
作者：
Gong, Fang [1 ]
Su, Qiang [2 ,3 ]
Pan, Yu Hong [1 ]
Huang, Xuan [1 ]
Shen, Wei Hong [1 ]
机构：
[1] Nantong Univ, Hosp 3, Dept Lab Med, 585 North Xingyuan Rd, Wuxi 214041, Jiangsu, Peoples R China
[2] Nantong Univ, Hosp 3, Dept Pulm Med, Wuxi 214041, Jiangsu, Peoples R China
[3] Nantong Univ, Hosp 3, Dept Allergy & Clin Immunol, Wuxi 214041, Jiangsu, Peoples R China
来源：
BIOMEDICAL REPORTS | 2013年 / 1卷 / 06期
关键词：
interleukin-21; atopic dermatitis; allergic rhinitis; atopic asthma;
D O I：
10.3892/br.2013.166
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Interleukin ( IL)-21 is a newly discovered member of the type I cytokine family. Since its discovery in 2000, IL-21 has been the focus of extensive investigation, due to its homology to IL-2, IL-4 and IL-15 and its pleiotropic effects on innate and adaptive immune responses. An increasing amount of experimental evidence supports a role for IL-21 in the pathogenesis of several allergic diseases, such as allergic rhinitis, atopic dermatitis (AD) and atopic asthma. In this review, we aimed to discuss the biological characteristics of IL-21 and summarize the current progress on the role of IL-21 in the regulation of allergic inflammation.
引用
收藏
页码：837 / 839
页数：3
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