EFFECTS OF ANTITHROMBIN-III (AT-III) AND TRP49-MODIFIED AT-III ON PLASMA-LEVEL OF 6-KETO-PGF1-ALPHA IN RATS

被引:48
作者
UCHIBA, M
OKAJIMA, K
MURAKAMI, K
OKABE, H
TAKATSUKI, K
机构
[1] KUMAMOTO UNIV, SCH MED, DEPT LAB MED, KUMAMOTO 860, JAPAN
[2] KUMAMOTO UNIV, SCH MED, DEPT MED, KUMAMOTO 860, JAPAN
关键词
ANTITHROMBIN III; PROSTACYCLIN; GLYCOSAMINOGLYCANS; ARTERIAL THROMBOSIS;
D O I
10.1016/0049-3848(95)00168-Q
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We evalutated the effect of antithrombin III (AT III) on the plasma level of 6-keto-PGF1 alpha in rats to determine whether AT III may promote the release of prostacyclin (PGl2) from endothelial cells in vivo. The intravenous administration of AT III (250U/kg) significantly increased the plasma levels of 6-keto-PGF1 alpha, with a peak seen 90 min post-administration. Neither Trp49-modified AT III, which lacks affinity for heparin but retains an inhibitory capacity for thrombin, nor heparin plus AT III, increased the plasma level of 6-keto-PGF1 alpha 90 min after administration. Indomethacin pretreatment inhibited the increase in plasma levels of 6-keto PGF1 alpha produced by AT III. Observations suggest that AT III may promote the release of PGl2 from endothelial cells by interacting with heparin-like glycosaminoglycans in vivo, consistent with previous observations in cultured endothelial cells.
引用
收藏
页码:201 / 208
页数:8
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