MICROWAVES IN THE INDUCTION OF IMMUNE-RESPONSE TO VI-ANTIGEN

In this work the possibility of using microwaves (MW) for immunomodulation in the immunization of animals with thymus-independent antigen was studied. The projection zones of the thyroid and adrenal glands of the test animals were subjected to the action of decimeter MW, while the corresponding zones of control animals were subjected to imitation MW. The endocrine activity of rabbits was estimated by radioimmune methods. Vi-antigen was shown to be a thymus-independent antigen for rabbits, according to the results of fluorescent probes to study the structural rearrangements in surfaces of thymocyte membranes and their nuclei, which reflect early changes during the physiological activation of cells. The irradiation by MW on the projection zone of the thyroid was accompanied by a decrease in the glucocorticoid activity of the adrenal cortex and a simultaneous pronounced immunostimulating effect, MW irradiation of the zone of the adrenal glands was accompanied by immunosuppression in combination with enhanced glucocorticoid activity of the adrenal cortex.