PROSTAGLANDIN AND THROMBOXANE BIOSYNTHESIS

被引：373
作者：
SMITH, WL [1 ]
MARNETT, LJ [1 ]
DEWITT, DL [1 ]
机构：
[1] VANDERBILT UNIV, MED CTR,SCH MED,CTR MOLEC TOXICOL,DEPT BIOCHEM, AB HANCOCK JR MEM LAB CANC RES, NASHVILLE, TN 37232 USA
来源：
PHARMACOLOGY & THERAPEUTICS | 1991年 / 49卷 / 03期
关键词：
D O I：
10.1016/0163-7258(91)90054-P
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We describe the enzymological regulation of the formation of prostaglandin (PG) D2, PGE2, PGF2-alpha, 9-alpha, 11-beta-PGF2, PGI2 (prostacyclin), and thromboxane (Tx) A2 from arachidonic acid. We discuss the three major steps in prostanoid formation: (a) arachidonate mobilization from monophosphatidyl-inositol involving phospholipase C, diglyceride lipase, and monoglyceride lipase and from phosphatidyl-choline involving phospholipase A2; (b) formation of prostaglandin endoperoxides (PGG2 and PGH2) catalyzed by the cyclooxygenase and peroxidase activities of PGH synthase; and (c) synthesis of PGD2, PGE2, PGF2-alpha, 9-alpha, 11-beta-PGF2, PGI2, and TxA2 from PGH2. We also include information on the roles of aspirin and other nonsteroidal anti-inflammatory drugs, dexamethasone and other anti-inflammatory steroids, platelet-derived growth factor (PDGF), and interleukin-1 in prostaglandin metabolism.
引用
收藏
页码：153 / 179
页数：27
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