POSSIBLE SELECTIVE EFFECTS OF INTERFERON ALPHA-2B ON A MALIGNANT CLONE IN A CASE OF POLYCYTHEMIA-VERA

被引：39

作者：

HINO, M

FUTAMI, E

OKUNO, S

MIKI, T

NISHIZAWA, Y

MORII, H

机构：

[1] Second Department of Internal Medicine, Osaka City University Medical School, Osaka, 545, 1-5-7, Asahi-machi, Abeno-ku

来源：

ANNALS OF HEMATOLOGY | 1993年 / 66卷 / 03期

关键词：

POLYCYTHEMIA VERA; INTERFERON; TRANSLOCATION; IGA;

D O I：

10.1007/BF01697629

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A patient with polycythemia vera associated with chromosomal translocation (6; 8) (q 27; p 11) and IgA monoclonal gammopathy was treated with interferon alpha-2b. Interferon alpha-2b induced good hematological control and reduced only IgA levels, but not IgG and IgM levels. In addition, cytogenetic improvement was obtained, the abnormal cells with chromosomal translocation declining from 100% to 50%. Interferon a may have selective effects on a malignant clone in polycythemia vera.

引用

页码：161 / 162

页数：2

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