MODULATION OF COFACTOR REQUIREMENT FOR THE ACTIVATION OF PROTEIN-KINASE-C BY HEPARIN - POSSIBLE EFFECT AT THE REGULATORY DOMAIN

被引：10
|
作者：
GOUELI, SA
HANTEN, JA
AHMED, K
机构：
[1] US DEPT VET AFFAIRS,MED CTR,1 VET DR,MINNEAPOLIS,MN 55417
[2] UNIV MINNESOTA,SCH MED,CELLULAR & MOLEC BIOCHEM LAB 151,MINNEAPOLIS,MN 55455
[3] UNIV MINNESOTA,SCH MED,DEPT LAB MED & PATHOL,MINNEAPOLIS,MN 55455
来源：
FEBS LETTERS | 1991年 / 282卷 / 02期
关键词：
PROTEIN KINASE-C; HEPARIN; PHOSPHORYLATION; REGULATORY DOMAIN;
D O I：
10.1016/0014-5793(91)80533-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Heparin was found to stimulate the phosphorylation of histone H1 but not protamine sulfate catalyzed by Ca2+/phospholipid-dependent protein kinase (protein kinase C or PKC). The effect of heparin on histone H1 phosphorylation appeared to be due to an increase in phosphatidylserine affinity of PKC activation in the presence of heparin. This effect of heparin was abolished when trypsinized, cofactor-independent, PKC was employed to phosphorylate histone H1. These studies suggest that heparin acts at the regulatory domain of PKC, and emphasize the importance of the negative charge in influencing the accessibility of the substrate to PKC action.
引用
收藏
页码：445 / 448
页数：4
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