Clinical Considerations of BRCA1-and BRCA2-Mutation Carriers: A Review

被引：31
作者：
Bougie, O. [1 ]
Weberpals, J. I. [2 ,3 ]
机构：
[1] Ottawa Hosp, Dept Obstet Gynaecol & Newborn Care, Ottawa, ON K1H 8L6, Canada
[2] Ottawa Hosp, Ottawa Hosp Res Inst, Ctr Canc Therapeut, Ottawa, ON K1H 8L6, Canada
[3] Ottawa Hosp, Div Gynaecol Oncol, Ottawa, ON K1H 8L6, Canada
来源：
INTERNATIONAL JOURNAL OF SURGICAL ONCOLOGY | 2011年 / 2011卷
关键词：
D O I：
10.1155/2011/374012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Individuals who carry an inheritedmutation in the breast cancer 1 (BRCA1) and BRCA2 genes have a significant risk of developing breast and ovarian cancer over the course of their lifetime. As a result, there are important considerations for the clinician in the counseling, followup and management of mutation carriers. This review outlines salient aspects in the approach to patients at high risk of developing breast and ovarian cancer, including criteria for genetic testing, screening guidelines, surgical prophylaxis, and chemoprevention.
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页数：11
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