SITE-SPECIFIC RECOMBINASES - TOOLS FOR GENOME ENGINEERING

被引：275
作者：
KILBY, NJ
SNAITH, MR
MURRAY, JAH
机构：
[1] N.J. Kilby, M.R. Snaith and J.A.H. Murray are in the Institute of Biotechnology, University of Cambridge, Cambridge, CB2 1QT, Tennis Court Road
来源：
TRENDS IN GENETICS | 1993年 / 9卷 / 12期
关键词：
D O I：
10.1016/0168-9525(93)90104-P
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Site-specific recombinases, from bacteriophage and yeasts have been developed as novel tools for manipulating DNA both in the test-tube and in living organisms. We discuss the characteristics of these enzyme systems, review their application in genetic and developmental studies and speculate on their future potential for large-scale directed modifications of eukaryotic genomes.
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收藏
页码：413 / 421
页数：9
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