INVITRO ACTIVITY OF AZITHROMYCIN AGAINST CLINICAL ISOLATES OF LEGIONELLA SPECIES

被引：72
作者：
EDELSTEIN, PH [1 ]
EDELSTEIN, MAC [1 ]
机构：
[1] UNIV PENN,SCH MED,DEPT MED,PHILADELPHIA,PA 19104
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 01期
关键词：
D O I：
10.1128/AAC.35.1.180
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The activities of azithromycin, erythromycin, and ciprofloxacin against 21 Legionella isolates were measured by an agar dilution method and in macrophages. The MICs for 90% of strains tested were 2.0, 1.0, and 0.5-mu-g/ml for azithromycin, erythromycin, and ciprofloxacin, respectively. Azithromycin and ciprofloxacin were both bactericidal in the macrophage system, but erythromycin was bacteriostatic.
引用
收藏
页码：180 / 181
页数：2
相关论文
共 9 条
[1]   AZITHROMYCIN, A MACROLIDE ANTIBIOTIC WITH POTENT ACTIVITY AGAINST TOXOPLASMA-GONDII [J].
ARAUJO, FG ;
GUPTILL, DR ;
REMINGTON, JS .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (05) :755-757
[2]   ACTIVITIES OF AMIKACIN, ROXITHROMYCIN, AND AZITHROMYCIN ALONE OR IN COMBINATION WITH TUMOR NECROSIS FACTOR AGAINST MYCOBACTERIUM-AVIUM COMPLEX [J].
BERMUDEZ, LEM ;
YOUNG, LS .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (08) :1149-1153
[3]   WIN-57273 IS BACTERICIDAL FOR LEGIONELLA-PNEUMOPHILA GROWN IN ALVEOLAR MACROPHAGES [J].
EDELSTEIN, PH ;
EDELSTEIN, MAC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (12) :2132-2136
[4]  
EDELSTEIN PH, 1985, 86129871 NAT TECHN I
[5]   EFFICACY OF AZITHROMYCIN IN THE TREATMENT OF GUINEA-PIGS INFECTED WITH LEGIONELLA-PNEUMOPHILA BY AEROSOL [J].
FITZGEORGE, RB ;
FEATHERSTONE, ASR ;
BASKERVILLE, A .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 25 :101-108
[6]   THE PHARMACOKINETICS OF AZITHROMYCIN IN HUMAN SERUM AND TISSUES [J].
FOULDS, G ;
SHEPARD, RM ;
JOHNSON, RB .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 25 :73-82
[7]   INVITRO AND INVIVO UPTAKE OF AZITHROMYCIN (CP-62,993) BY PHAGOCYTIC-CELLS - POSSIBLE MECHANISM OF DELIVERY AND RELEASE AT SITES OF INFECTION [J].
GLADUE, RP ;
BRIGHT, GM ;
ISAACSON, RE ;
NEWBORG, MF .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (03) :277-282
[8]   SPECTRUM AND MODE OF ACTION OF AZITHROMYCIN (CP-62,993), A NEW 15-MEMBERED-RING MACROLIDE WITH IMPROVED POTENCY AGAINST GRAM-NEGATIVE ORGANISMS [J].
RETSEMA, J ;
GIRARD, A ;
SCHELKLY, W ;
MANOUSOS, M ;
ANDERSON, M ;
BRIGHT, G ;
BOROVOY, R ;
BRENNAN, L ;
MASON, R .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (12) :1939-1947
[9]   PHARMACOKINETICS OF AZITHROMYCIN IN RATS AND DOGS [J].
SHEPARD, RM ;
FALKNER, FC .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 25 :49-60
1