TENOXICAM CONCENTRATIONS IN SYNOVIUM AND JOINT CARTILAGE IN HUMANS

被引：17
作者：
BANNWARTH, B
NETTER, P
LAPICQUE, F
MAINARD, D
FENER, P
GILLET, P
GAUCHER, A
机构：
[1] CTR HOSP REG & UNIV NANCY BRABOIS,SERV CHIRURG ORTHOPED & TRAUMATOL,F-54511 VANDOEUVRE NANCY,FRANCE
[2] CTR HOSP REG & UNIV NANCY BRABOIS,RHUMATOL CLIN,NANCY,FRANCE
来源：
AGENTS AND ACTIONS | 1991年 / 32卷 / 3-4期
关键词：
D O I：
10.1007/BF01980889
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Tenoxicam is an NSAID of the oxicam group. Its distribution in articular tissues was investigated in 12 patients who required total arthroplasty of the hip. They were given tenoxicam 20 mg once daily for 8 to 30 days before surgery. Blood, synovium and cartilage samples were taken concurrently during surgery, about 14 hours after the last tenoxicam dose. The tissues were ground using a freeze grinder. Tenoxicam was assayed by HPLC. Tenoxicam concentrations averaged 6.21 +/- 3.81-mu-g/ml in plasma, 7.56 +/- 4.67-mu-g/g in synovium and 2.05 +/- 1.43-mu-g/g in cartilage. The individual synovium/cartilage ratios ranged from 1.9 to 9.7. Finally tenoxicam exhibited more affinity for its target organ (synovial tissue) than for joint cartilage.
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页码：295 / 298
页数：4
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