SUPPRESSION OF TERMINATION CODONS IN HIGHER EUKARYOTES

被引：67

作者：

HATFIELD, D

机构：

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1985年 / 10卷 / 05期

关键词：

D O I：

10.1016/0968-0004(85)90192-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Introduction of nonsense suppressor tRNAs or genes encoding nonsense suppressor tRNAs into cells of higher eukaryotes shows that these tRNAs or tRNA gene products suppress the corresponding termination codons, UAA, UAG and UGA. On the other hand, most of the natural suppression in higher eukaryotes involves misreading of termination codons by major cytoplasmic aminoacyl-tRNAs, while naturally occurring suppressor tRNAs appear to have very specialized cellular functions. © 1985.

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页码：201 / 204

页数：4

相关论文

共 30 条

[1] UAG READTHROUGH DURING TMV RNA TRANSLATION - ISOLATION AND SEQUENCE OF 2 TRANSFER RNASTYR WITH SUPPRESSOR ACTIVITY FROM TOBACCO PLANTS [J].

BEIER, H ;

BARCISZEWSKA, M ;

KRUPP, G ;

MITNACHT, R ;

GROSS, HJ .

EMBO JOURNAL, 1984, 3 (02) :351-356

[2] THE MOLECULAR-BASIS FOR THE DIFFERENTIAL TRANSLATION OF TMV RNA IN TOBACCO PROTOPLASTS AND WHEAT-GERM EXTRACTS [J].

BEIER, H ;

BARCISZEWSKA, M ;

SICKINGER, HD .

EMBO JOURNAL, 1984, 3 (05) :1091-1096

[3] NONSENSE SUPPRESSION IN EUKARYOTES - THE USE OF THE XENOPUS-OOCYTE AS AN INVIVO ASSAY SYSTEM [J].

BIENZ, M ;

KUBLI, E ;

KOHLI, J ;

DEHENAU, S ;

GROSJEAN, H .

NUCLEIC ACIDS RESEARCH, 1980, 8 (22) :5169-5178

[4] USAGE OF THE 3 TERMINATION CODONS IN A SINGLE EUKARYOTIC CELL, THE XENOPUS-LAEVIS OOCYTE [J].

BIENZ, M ;

KUBLI, E ;

KOHLI, J ;

DEHENAU, S ;

HUEZ, G ;

MARBAIX, G ;

GROSJEAN, H .

NUCLEIC ACIDS RESEARCH, 1981, 9 (15) :3835-3850

[5] WILD-TYPE TRANSFER-RNA GTYR READS THE TMV RNA STOP CODON, BUT Q-BASE-MODIFIED TRANSFER-RNA GTYR DOES NOT [J].

BIENZ, M ;

KUBLI, E .

NATURE, 1981, 294 (5837) :188-190

[6] THE SUP-7(ST5) X-GENE OF CAENORHABDITIS-ELEGANS ENCODES A TRANSFER RNA-TRP-UAG AMBER SUPPRESSOR [J].

BOLTEN, SL ;

POWELLABEL, P ;

FISCHHOFF, DA ;

WATERSTON, RH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (21) :6784-6788

[7] ISOLATION OF A SUPPRESSIBLE NONSENSE MUTANT IN MAMMALIAN-CELLS [J].

CAPECCHI, MR ;

VONDERHAAR, RA ;

CAPECCHI, NE ;

SVEDA, MM .

CELL, 1977, 12 (02) :371-381

[8] NONSENSE SUPPRESSORS IN EUKARYOTES [J].

CELIS, JE ;

PIPER, PW .

TRENDS IN BIOCHEMICAL SCIENCES, 1981, 6 (07) :177-179

[9] INVITRO SUPPRESSION OF UAG AND UGA MUTANTS IN THE THYMIDINE KINASE GENE OF HERPES-SIMPLEX VIRUS [J].

CREMER, KJ ;

BODEMER, M ;

SUMMERS, WP ;

SUMMERS, WC ;

GESTELAND, RF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (01) :430-434

[10]

DIAMOND, 1981, CELL, V25, P497