Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N, N-Diethyl-Substituted Amido Moieties

Sulfonamide drugs which have brought about an antibiotic revolution in medicine are associated with a wide range of biological activities. We have synthesized a series of a-tolylsulfonamide, 1-11 and their substituted N, N-diethyl-2-(phenylmethylsulfonamido) alkanamide derivatives, 12-22 in improved and excellent yields in aqueous medium at room temperature through highly economical synthetic routes. The chemical structures of the synthesized compounds 1-22 were confirmed by analytical and spectral data such as IR, H-1-and C-13-NMR, andmass spectra. The in vitro antibacterial activity of these compounds along with standard clinical reference, streptomycin, was investigated on two key targeted organisms. It was observed that 1-(benzylsulfonyl) pyrrolidine-2-carboxylic acid, 2 emerged as the most active compound against Staphylococcus aureus at MIC value of 1.8 mu g/mL while 4-(3-(diethylamino)-3-oxo-2-(phenylmethylsulfonamido) propyl) phenyl phenylmethanesulfonate, 22 was the most active sulfonamide scaffold on Escherichia coli at MIC value of 12.5 mu g/mL.