ERYTHROPOIETIN AS A MITOGEN FOR FETAL LIVER STROMAL CELLS WHICH SUPPORT ERYTHROPOIESIS

被引:27
作者
OHNEDA, O [1 ]
YANAI, N [1 ]
OBINATA, M [1 ]
机构
[1] TOHOKU UNIV,INST DEV AGING & CANC,DEPT CELL BIOL,SEIRYO MACHI 4-1,AOBA KU,SENDAI,MIYAGI 980,JAPAN
关键词
D O I
10.1006/excr.1993.1253
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Fetal liver stromal cells established from 13-day-old embryos support erythropoiesis in vitro in combination with erythropoietin (Epo). Epo stimulated growth of these stromal cells in a dose-dependent manner and mRNA for Epo receptor was detected. These results suggest the possible involvement of Epo in the generation of the fetal erythropoietic microenvironment during development. © 1993 Academic Press, Inc.
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页码:327 / 331
页数:5
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