DOES THE CEREBELLUM PROVIDE A COMMON COMPUTATION FOR DIVERSE TASKS - A TIMING HYPOTHESIS

被引:192
作者
KEELE, SW [1 ]
IVRY, R [1 ]
机构
[1] UNIV OREGON, DEPT PSYCHOL, EUGENE, OR 97403 USA
关键词
D O I
10.1111/j.1749-6632.1990.tb48897.x
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The cerebellum provides a temporal computation for a number of tasks. We have found that the accuracy in timing motor responses is correlated across different motor effectors. Moreover, perceptual acuity in judging durations of auditory intervals is correlated with motoric measures of timing. These results suggest a common process underlying timing of different sorts, and that this process may depend on a specific neural system. Our data indicate that damage to the cerebellum impairs motor and perceptual timing. Patients with cerebellar lesions are also impaired at judging the velocity of a moving visual stimulus, a process that would appear to require precise timing. Furthermore, the lateral cerebellum has been implicated in classical "eyeblink" conditioning of the rabbit's nictitating membrane response. Because classical conditioning of discrete, adaptive responses is precisely timed, we argue that the cerebellum is the conditioning site for this response because of the need for temporal computation. Classical conditioning of responses such as of heart rate, which is not so precisely timed, does not depend on the cerebellum. The cerebellar influence on locomotion may also be one of providing temporal information. Clumsy children appear as a group to have poor timing, not only on motor production but on perception as well, as would be expected if a general computation is impaired. Because of the importance of the discovery of a cerebellar role in classical conditioning, we begin our argument with respect to classical conditioning.
引用
收藏
页码:179 / 211
页数:33
相关论文
共 83 条
[1]  
ADAMS RD, 1985, PRINCIPLES NEUROLOGY
[2]  
ALBUS J S, 1971, Mathematical Biosciences, V10, P25, DOI 10.1016/0025-5564(71)90051-4
[3]   PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX [J].
ALEXANDER, GE ;
DELONG, MR ;
STRICK, PL .
ANNUAL REVIEW OF NEUROSCIENCE, 1986, 9 :357-381
[4]   CEREBROCEREBELLAR COMMUNICATION SYSTEMS [J].
ALLEN, GI ;
TSUKAHARA, N .
PHYSIOLOGICAL REVIEWS, 1974, 54 (04) :957-1006
[5]   CEREBELLAR DEGENERATION ASSOCIATED WITH CHRONIC ALCOHOLISM [J].
ALLSOP, J ;
TURNER, B .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1966, 3 (03) :238-&
[6]   THE CEREBELLUM AND CONTROL OF RHYTHMICAL MOVEMENTS [J].
ARSHAVSKY, YI ;
GELFAND, IM ;
ORLOVSKY, GN .
TRENDS IN NEUROSCIENCES, 1983, 6 (10) :417-422
[7]   BRAIN-STEM AND SPINAL PROJECTIONS OF THE DEEP CEREBELLAR NUCLEI IN THE MONKEY, WITH OBSERVATIONS ON THE BRAIN-STEM PROJECTIONS OF THE DORSAL COLUMN NUCLEI [J].
ASANUMA, C ;
THACH, WT ;
JONES, EG .
BRAIN RESEARCH REVIEWS, 1983, 5 (03) :299-322
[8]   DISTRIBUTION OF CEREBELLAR TERMINATIONS AND THEIR RELATION TO OTHER AFFERENT TERMINATIONS IN THE VENTRAL LATERAL THALAMIC REGION OF THE MONKEY [J].
ASANUMA, C ;
THACH, WT ;
JONES, EG .
BRAIN RESEARCH REVIEWS, 1983, 5 (03) :237-265
[9]   ANATOMICAL EVIDENCE FOR SEGREGATED FOCAL GROUPINGS OF EFFERENT CELLS AND THEIR TERMINAL RAMIFICATIONS IN THE CEREBELLO-THALAMIC PATHWAY OF THE MONKEY [J].
ASANUMA, C ;
THACH, WT ;
JONES, EG .
BRAIN RESEARCH REVIEWS, 1983, 5 (03) :267-269
[10]  
Braitenberg V, 1967, Prog Brain Res, V25, P334