Diagnostic challenges in a patient with an occult insulinoma:Ga-68-DOTA-exendin-4 PET/CT and Ga-68-DOTATATE PET/CT

被引：15

作者：

Bongetti, Elisa ^{[1
]}

Lee, Melissa H. ^{[1
,6
]}

Pattison, David A. ^{[2
,3
]}

Hicks, Rodney J. ^{[2
,4
]}

Norris, Richard ^{[5
]}

Sachithanandan, Nirupa ^{[1
]}

MacIsaac, Richard J. ^{[1
,6
]}

机构：

[1] St Vincents Hosp, Dept Endocrinol & Diabet, Melbourne, Vic, Australia

[2] Peter MacCallum Canc Ctr, Ctr Canc Imaging, Melbourne, Vic, Australia

[3] Royal Brisbane & Womens Hosp, Dept Nucl Med & Specialised PET Serv, Brisbane, Qld, Australia

[4] Peter MacCallum Canc Ctr, Neuroendocrine Serv, Melbourne, Vic, Australia

[5] St Vincents Hosp, Dept Pathol, Melbourne, Vic, Australia

[6] Univ Melbourne, Dept Med, Melbourne, Vic, Australia

来源：

CLINICAL CASE REPORTS | 2018年 / 6卷 / 04期

关键词：

adenoma; diagnostic imaging; endocrine gland neoplasms; insulinoma; Islet cell; molecular imaging; nesidioblastosis; pancreatic neoplasms;

D O I：

10.1002/ccr3.1448

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Key Clinical Message Despite growing evidence for GLP-1R molecular-based imaging, successful localization of insulinomas may require the use of multiple imaging modalities. Not all benign insulinomas express the GLP-1R as expected. Our case demonstrates that there is a still an important role for traditional methods for the anatomical localization of an insulinoma.

引用

页码：719 / 722

页数：4

共 9 条

[1] Preoperative localization of adult nesidioblastosis using 68Ga-DOTA-exendin-4-PET/CT [J].

Christ, Emanuel ;

Wild, Damian ;

Antwi, Kwadwo ;

Waser, Beatrice ;

Fani, Melpomeni ;

Schwanda, Stefanie ;

Heye, Tobias ;

Schmid, Christoph ;

Baer, Hans Ulrich ;

Perren, Aurel ;

Reubi, Jean Claude .

ENDOCRINE, 2015, 50 (03) :821-823

[2] Glucagon-like peptide-1 receptor imaging for the localisation of insulinomas: a prospective multicentre imaging study [J].

Christ, Emanuel ;

Wild, Damian ;

Ederer, Susanne ;

Behe, Martin ;

Nicolas, Guillaume ;

Caplin, Martyn E. ;

Braendle, Michael ;

Clerici, Thomas ;

Fischli, Stefan ;

Stettler, Christoph ;

Ell, Peter J. ;

Seufert, Jochen ;

Gloor, Beat ;

Perren, Aurel ;

Reubi, Jean Claude ;

Forrer, Flavio .

LANCET DIABETES & ENDOCRINOLOGY, 2013, 1 (02) :115-122

[3] Glucagon-Like Peptide-1 Receptor PET/CT with 68Ga-NOTA-Exendin-4 for Detecting Localized Insulinoma: A Prospective Cohort Study [J].

Luo, Yaping ;

Pan, Qingqing ;

Yao, Shaobo ;

Yu, Miao ;

Wu, Wenming ;

Xue, Huadan ;

Kiesewetter, Dale O. ;

Zhu, Zhaohui ;

Li, Fang ;

Zhao, Yupei ;

Chen, Xiaoyuan .

JOURNAL OF NUCLEAR MEDICINE, 2016, 57 (05) :715-720

[4] Pancreatic Imaging [J].

Masciocchi, Mark .

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2017, 46 (03) :761-+

[5]

Negrean Vasile, 2013, Clujul Med, V86, P377

[6] Localization of Insulinoma Using 68Ga-DOTATATE PET/CT Scan [J].

Nockel, Pavel ;

Babic, Bruna ;

Millo, Corina ;

Herscovitch, Peter ;

Patel, Dhaval ;

Nilubol, Naris ;

Sadowski, Samira M. ;

Cochran, Craig ;

Gorden, Phillip ;

Kebebew, Electron .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2017, 102 (01) :195-199

[7] Diagnosis and management of insulinoma [J].

Okabayashi, Takehiro ;

Shima, Yasuo ;

Sumiyoshi, Tatsuaki ;

Kozuki, Akihito ;

Ito, Satoshi ;

Ogawa, Yasuhiro ;

Kobayashi, Michiya ;

Hanazaki, Kazuhiro .

WORLD JOURNAL OF GASTROENTEROLOGY, 2013, 19 (06) :829-837

[8] Molecular imaging in the investigation of hypoglycaemic syndromes and their management [J].

Pattison, David A. ;

Hicks, Rodney J. .

[9] Complications of bariatric surgery: Dumping syndrome, reflux and vitamin deficiencies [J].

Tack, Jan ;

Deloose, Eveline .

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2014, 28 (04) :741-749

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