Relationship TG/HDL-C and insulin resistance in adult women by nutritional status

Introduction: The ratio assessment TG/HDL-C is an indicator of LDL size, facilitating the detection of individuals with increased atherogenic risk. Estimating the size of the LDL becomes important, especially in patients with TG values near the upper limit of normal values of reference and HDL-C. The objective of the study is to estimate the association between TG/HDL-C and insulin resistance (IR) by nutritional status in adult women attending the Foundation for Endocrine Metabolic Diseases Research and Applied Clinical Research (FIEEM). Material and methods: Design Cross-sectional, non-pregnant adult women, apparently healthy, older than 30 years old, attending FIEEM in the Autonomous City of Buenos Aires. Dependent variable: TG/HDL-C >= 3.0 considered high value. Independent variables: IR by homeostatic model index HOMA-IR >= 2.5 categorizing the sample into two groups: with and without IR, and controlled by nutritional status using body mass index (BMI) and waist circumference (CC). SPSS Statistics 15.0, calculating X-2 or Fisher exact test, OR with confidence intervals of 95% and establishing logistic regression p value < 0.05. Results: We evaluated a purposive sample of 104 women (31.4% and 26% IR with TG/HDL-C high). 84.6% were overweight or obese and 88.5% increased CC. Women with BMI had significantly increased 0.15-fold increased risk (95% CI = 0.01 to 1.26) for TG/HDL-C high (p = 0.04) than the control women. There was no significance with increased CC. The ratio TG/HDL-C high IR was significantly correlated (r = 0.30 p = 0.002). Conclusions: Body weight was significantly associated with IR and the ratio TG/HDL-C increased. This ratio correlated significantly with IR in apparently healthy women.