EXPRESSION SCREENING REVEALS AN ORPHAN RECEPTOR CHICK OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR-I AS A REGULATOR OF NEURITE SUBSTRATE-CELL CONTACTS AND CELL-AGGREGATION

被引：14

作者：

CONNOR, H ^{[1
]}

NORNES, H ^{[1
]}

NEUMAN, T ^{[1
]}

机构：

[1] COLORADO STATE UNIV,DEPT ANAT & NEUROBIOL,FT COLLINS,CO 80523

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1995年 / 270卷 / 25期

关键词：

D O I：

10.1074/jbc.270.25.15066

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A rat homologue of chick ovalbumin upstream promoter transcription factor I (COUP-TF I) was isolated using an expression cloning method developed to isolate neurite outgrowth inhibitors. Overexpression of COUP-TF I in 3T3 fibroblasts resulted in reduction of stable contact formation between neurites and transfected cells. Additionally, COUP-TF I enhanced retinoic acid response element-dependent reporter gene expression in 3T3 fibroblasts, indicating that COUP-TF I can modulate transcriptional activation in these cells. Our data suggest that COUP-TF transcription factors are involved in the regulation of cell surface molecules during neurogenesis.

引用

页码：15066 / 15070

页数：5

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