ANTI-AIDS AGENTS .19. NEOTRIPTERIFORDIN, A NOVEL ANTI-HIV PRINCIPLE FROM TRIPTERYGIUM-WILFORDII - ISOLATION AND STRUCTURAL ELUCIDATION

被引：39

作者：

CHEN, K

SHI, QA

FUJIOKA, T

NAKANO, T

HU, CQ

JIN, JQ

KILKUSKIE, RE

LEE, KH

机构：

[1] UNIV N CAROLINA,SCH PHARM,DIV MED CHEM & NAT PROD,NAT PROD LAB,CHAPEL HILL,NC 27599

[2] SHANGHAI MED UNIV,SCH PHARM,DEPT CHEM NAT DRUGS,SHANGHAI 200032,PEOPLES R CHINA

[3] BIOTECH RES LABS INC,ROCKVILLE,MD 20850

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1995年 / 3卷 / 10期

关键词：

D O I：

10.1016/0968-0896(95)00114-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new kaurane type diterpene lactone, neotripterifordin (1), has been isolated from the roots of Tripterygium wilfordii. The structure of 1 was elucidated by spectroscopic methods, which included the concerted application of a number of 2-D NMR techniques including H-1-H-1 COSY, phase-sensitive NOESY, HETCOR, and long-range HETCOR. Compound 1 showed anti-HIV replication activity in H9 lymphocyte cells with an EC(50) of 25 nM and TI of 125.

引用

页码：1345 / 1348

页数：4

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