EFFECTS OF SUBCHRONIC TREATMENT WITH TRANDOLAPRIL AND ENALAPRIL ON CARDIOVASCULAR MORPHOLOGIC ALTERATIONS IN THE AGED SPONTANEOUSLY HYPERTENSIVE RAT WITH HEART-FAILURE

被引:0
作者
SECCHI, J [1 ]
LECAQUE, D [1 ]
DUNN, FW [1 ]
JOUQUEY, S [1 ]
AUBERVAL, UD [1 ]
BENZONI, F [1 ]
SIRUGUE, O [1 ]
HAMON, G [1 ]
机构
[1] ROUSSEL UCLAF,CTR RECH,F-93230 ROMAINVILLE,FRANCE
关键词
TRANDOLAPRIL; ENALAPRIL; HYPERTENSION; SUBCHRONIC TREATMENT;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effects of a 3-month treatment period with the angiotensin-converting enzyme (ACE) inhibitors trandolapril (0.3 mg/kg/day, p.o.) and enalapril (10 mg/kg/day, p.o.) on hemodynamics, cardiac hypertrophy, and vascular structures were examined in old spontaneously hypertensive rats (SHRs) (24 months at the end of treatment) presenting with congestive heart failure. During the course of treatment, the mortality rate was lower in the two treated groups than in the control group. At the end of treatment, serum ACE activity was inhibited by 63 and 33% by trandolapril and enalapril, respectively, but the decrease in blood pressure they induced was not significant. The atrial natriuretic factor (ANF) plasma levels and cyclic GMP urine excretion were about 10-fold and 3-fold higher, respectively, in old SHRs than in old Wistar rats. These values were markedly decreased by both ACE inhibitors. The ventricular hypertrophy was greatly decreased by both compounds (-24% by trandolapril and -26% by enalapril). In the aorta, the media hypertrophy was significantly decreased and nuclear density increased to a similar extent by both ACE inhibitors. In the mesenteric artery, trandolapril treatment induced a complete regression of the media hypertrophy and a marked decrease in extracellular matrix surface. In addition, the collagen network appeared less dissociated in the treated animals. Similarly the nuclear density was increased and the surface of cell nuclei was decreased by trandolapril. Enalapril appeared much less potent on these parameters. These data demonstrate that treatment with trandolapril of aged SHRs presenting with heart failure results in an increase in survival of the animals and a marked regression of cardiac and vascular hypertrophy. In addition, a protective action at the level of vascular structure could also be demonstrated in resistance vessels.
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页码:S30 / S37
页数:8
相关论文
共 32 条
[1]   POLYPLOID NUCLEI IN HUMAN ARTERY WALL SMOOTH-MUSCLE CELLS [J].
BARRETT, TB ;
SAMPSON, P ;
OWENS, GK ;
SCHWARTZ, SM ;
BENDITT, EP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (03) :882-885
[2]   ATRIAL-NATRIURETIC-PEPTIDE ELEVATION IN CONGESTIVE-HEART-FAILURE IN THE HUMAN [J].
BURNETT, JC ;
KAO, PC ;
HU, DC ;
HESER, DW ;
HEUBLEIN, D ;
GRANGER, JP ;
OPGENORTH, TJ ;
REEDER, GS .
SCIENCE, 1986, 231 (4742) :1145-1147
[3]  
CASANOVA P, 1974, ANN ANAT PATHOL, V19, P241
[4]   COMPARED PROPERTIES OF TRANDOLAPRIL, ENALAPRIL, AND THEIR DIACID METABOLITES [J].
CHEVILLARD, C ;
JOUQUEY, S ;
BREE, F ;
MATHIEU, MN ;
STEPNIEWSKI, JP ;
TILLEMENT, JP ;
HAMON, G ;
CORVOL, P .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1994, 23 :S11-S15
[5]  
CORBIER A, 1994, J CARDIOVASC PHARM, V23, pS26
[6]  
DUSSAULE JC, 1986, J PHARMACOL EXP THER, V236, P512
[7]   BENEFICIAL-EFFECTS OF TRANDOLAPRIL ON EXPERIMENTALLY INDUCED CONGESTIVE-HEART-FAILURE IN RATS [J].
FORNES, P ;
RICHER, C ;
PUSSARD, E ;
HEUDES, D ;
DOMERGUE, V ;
GIUDICELLI, JF .
AMERICAN JOURNAL OF CARDIOLOGY, 1992, 70 (12) :D43-D51
[8]   EFFECTS OF TRANDOLAPRIL ON VASCULAR MORPHOLOGY AND FUNCTION DURING THE ESTABLISHED PHASE OF SYSTEMIC HYPERTENSION IN THE SPONTANEOUSLY HYPERTENSIVE RAT [J].
FRESLON, JL ;
POURAGEAUD, F ;
LECAQUE, D ;
SECCHI, J .
AMERICAN JOURNAL OF CARDIOLOGY, 1992, 70 (12) :D35-D42
[9]  
HAMET P, 1986, J HYPERTENS, V4, pS49
[10]  
HARJANNE A, 1984, CLIN CHEM, V30, P901