PEPTIDE AZOLES - A NEW CLASS OF BIOLOGICALLY-ACTIVE DIPEPTIDE MIMETICS

被引：33

作者：

GORDON, T

HANSEN, P

MORGAN, B

SINGH, J

BAIZMAN, E

WARD, S

机构：

[1] STERLING WINTHROP PHARMACEUT, DIV RES, DEPT MED CHEM, RENSSELAER, NY 12144 USA

[2] STERLING WINTHROP PHARMACEUT, DIV RES, DEPT PHARMACOL, RENSSELAER, NY 12144 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(00)80692-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Appropriately substituted thiazoles, imidazoles and oxazoles have been designed to be useful mimetics of dipeptide moieties, These ''peptide azoles' have been shown to be potent antagonists of substance P as measured by isolated tissue assays such as the isolated guinea-pig ileum. A novel, chiral synthesis of these peptide azoles from aminoacids has been developed.

引用

页码：915 / 920

页数：6

共 15 条

[1]

BAIZMAN ER, 1984, PEPTIDES 1984, P359

[2]

CORNISHBOWDEN A, 1984, EUR J BIOCHEM, V138, P9, DOI 10.1111/j.1432-1033.1984.tb07877.x

[3] ANTAGONISTS OF SUBSTANCE-P - FURTHER MODIFICATIONS OF SUBSTANCE-P ANTAGONISTS OBTAINED BY REPLACING EITHER POSITIONS 7, 9 OR 7, 8 AND 11 OF SP WITH D-AMINO-ACID RESIDUES [J].