EFFECTS OF ENDOTHELIN-1 AND VASOPRESSIN ON RESISTANCE ARTERIES OF SPONTANEOUSLY HYPERTENSIVE RATS

被引：77
作者：
DENG, LY [1 ]
SCHIFFRIN, EL [1 ]
机构：
[1] CLIN RES INST MONTREAL, 110 PINE AVE W, MONTREAL H2W 1R7, QUEBEC, CANADA
来源：
AMERICAN JOURNAL OF HYPERTENSION | 1992年 / 5卷 / 11期
基金：
英国医学研究理事会;
关键词：
ENDOTHELIUM; VASOACTIVE PEPTIDES; VASCULAR REMODELING; WISTAR-KYOTO RATS; GENETIC HYPERTENSION;
D O I：
10.1093/ajh/5.11.817
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Previous studies have shown an impairment of responsiveness of resistance arteries to endothelin-1 in experimental hypertensive rats. This study was undertaken to demonstrate whether responses were also blunted in adult 20-week-old spontaneously hypertensive rats (SHR). Resistance arteries from the mesenteric vascular bed exhibited normal active tension responses to endothelin-1 and arginine vasopressin, and exaggerated responses to norepinephrine. Since the media was thicker in SHR, media stress responses to endothelin-1 and arginine vasopressin were significantly impaired, while norepinephrine media stress responses were similar in SHR and Wistar-Kyoto rats (WKY). Active pressure responses to endothelin-1, arginine vasopressin, and norepinephrine were significantly amplified by the narrowed lumen of blood vessels in SHR. Additionally, media cross-sectional area was similar in SHR and WKY, but was greater in SHR when normalized for the smaller body weight of the hypertensive rats. These results demonstrate the presence of remodeling in resistance arteries of 20-week-old SHR, and show that the altered morphology of these blood vessels may significantly amplify impaired wall stress responses to endothelin-1 and arginine vasopressin, which may contribute to elevation of blood pressure.
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收藏
页码：817 / 822
页数：6
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